基于CuS@MSN的治疗诊断纳米药物在体肿瘤血管靶向治疗
In VivoTumor Vasculature Targeting of CuS@MSN Based Theranostic Nanomedicine
作者:Feng Chen;Hao Hong;Shreya Goel;Stephen A. Graves;Hakan Orbay;Emily B. Ehlerding;Sixiang Shi;Charles P. Theuer;Robert J. Nickles;Weibo Cai;
关键词:vasculature targeting,CuS,mesoporous silica nanoparticle,theranostic nanomedicine,photothermal ablation
DOI:https://doi.org/10.1021/nn507241v
发表时间:2015年
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摘要
积极定向的治疗性纳米医学可能是未来个性化癌症管理的关键。尽管过去十年里已经开发出了许多类型的治疗性纳米颗粒用于癌症治疗,但在工程化具有高度特异的生物相容性治疗性纳米颗粒以实现 in vivo 肿瘤定向治疗能力方面仍存在挑战。在这里,我们报告了用于未来癌症管理的一类新型治疗性纳米颗粒的设计、合成、表面工程和 in vivo 活性血管定向靶向。水溶性光热敏感的硫化铜纳米颗粒被封装在生物相容性的介孔二氧化硅壳中,随后进行多步表面工程形成最终的治疗性纳米颗粒。系统的 in vitro 靶向、 in vivo 长期毒性研究、光热消融评估、 in vivo 血管靶向成像、生物分布和组织学研究被执行以充分探索所开发的治疗性纳米颗粒的潜力。
Abstract
Actively targeted theranostic nanomedicine may be the key for future personalized cancer management. Although numerous types of theranostic nanoparticles have been developed in the past decade for cancer treatment, challenges still exist in the engineering of biocompatible theranostic nanoparticles with highly specific in vivo tumor targeting capabilities. Here, we report the design, synthesis, surface engineering, and in vivo active vasculature targeting of a new category of theranostic nanoparticle for future cancer management. Water-soluble photothermally sensitive copper sulfide nanoparticles were encapsulated in biocompatible mesoporous silica shells, followed by multistep surface engineering to form the final theranostic nanoparticles. Systematic in vitro targeting, an in vivo long-term toxicity study, photothermal ablation evaluation, in vivo vasculature targeted imaging, biodistribution and histology studies were performed to fully explore the potential of as-developed new theranostic nanoparticles.
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