用于减少纳米颗粒与蛋白质相互作用的仿生聚乙二醇涂层
Bioinspired Polyethylene Glycol Coatings for Reduced Nanoparticle–Protein Interactions
作者:Jhoan Toro-Mendoza;Lucia Maio;Marta Gallego;Ferdinand Otto;Florian Schulz;Wolfgang J. Parak;Carlos Sanchez-Cano;Ivan Coluzza;
关键词:colloidal nanoparticles,polyethylene glycol,antifouling,protein adsorption,biomimetic surface coating,molecular dynamics
DOI:https://doi.org/10.1021/acsnano.2c05682
发表时间:2023年
- 文献详情
- 相似文献
摘要
纳米颗粒(NP)和其他工程纳米材料作为生物医学应用的纳米药物或纳米医疗设备具有巨大的潜力。然而,血液循环或类似生理液体中蛋白质的吸附可以显着改变大多数纳米材料引起的表面特性和治疗反应。例如,与蛋白质的相互作用可以改变血流循环时间和治疗性纳米粒子的可用性,或阻碍其在所需靶器官中的积累。蛋白质还可以引发或防止聚集。通过结合实验和计算方法,我们开发了携带聚乙二醇(PEG)聚合物涂层的纳米颗粒,该涂层模拟了血液中常见蛋白质的表面电荷分布,已知这些蛋白质在正常血液条件下表现出低聚集性。在这里,我们表明,与带有传统 PEG 聚合物涂层的类似 NP 相比,带有基于脱铁铁蛋白或人血清白蛋白涂层的 NP 显示出更好的防污性能和更弱的蛋白质相互作用。
Abstract
Nanoparticles (NPs) and other engineered nanomaterials have great potential as nanodrugs or nanomedical devices for biomedical applications. However, the adsorption of proteins in blood circulation or similar physiological fluids can significantly alter the surface properties and therapeutic response induced by most nanomaterials. For example, interaction with proteins can change the bloodstream circulation time and availability of therapeutic NPs or hinder the accumulation in their desired target organs. Proteins can also trigger or prevent agglomeration. By combining experimental and computational approaches, we have developed NPs carrying polyethylene glycol (PEG) polymeric coatings that mimic the surface charge distribution of proteins typically found in blood, which are known to show low aggregation under normal blood conditions. Here, we show that NPs with coatings based on apoferritin or human serum albumin display better antifouling properties and weaker protein interaction compared to similar NPs carrying conventional PEG polymeric coatings.
-
Ultrafast Interlayer Charge Transfer Outcompeting Intralayer Valley Relaxation in Few-Layer 2D Heterostructures
引用量:0发表时间:2023年
-
Vanadium Carbide Nanosheets with Broad-Spectrum Antioxidant Activity for Pulmonary Fibrosis Therapy
引用量:0发表时间:2023年
-
“Reaction”-Like Shaping of Self-Delivery Supramolecular Nanodrugs in the Nanoprecipitation Process
引用量:0发表时间:2023年
-
Vanadium Intercalation into Niobium Disulfide to Enhance the Catalytic Activity for Lithium–Sulfur Batteries
引用量:0发表时间:2023年
-
Mapping Antibody Domain Exposure on Nanoparticle Surfaces Using DNA-PAINT
引用量:0发表时间:2023年
-
Development of Multifunctional Nanoencapsulatedtrans-Resveratrol/Chitosan Nutraceutical Edible Coating for Strawberry Preservation
引用量:0发表时间:2023年
-
Solution-Processed Flexible Transparent Electrodes for Printable Electronics
引用量:0发表时间:2023年
-
Amorphizing Metal Selenides-Based ROS Biocatalysts at Surface Nanolayer toward Ultrafast Inflammatory Diabetic Wound Healing
引用量:0发表时间:2023年
-
Direct Imaging of “Patch-Clasping” and Relaxation in Robust and Flexible Nanoparticle Assemblies
引用量:0发表时间:2023年
-
An Integrated Multilevel Approach Unveils Complex Seed–Nanoparticle Interactions and Their Implications for Seed Priming
引用量:0发表时间:2023年