用于仿生组织工程的可定制坚韧水凝胶的可见光介导纳米生物矿化
Visible-Light-Mediated Nano-biomineralization of Customizable Tough Hydrogels for Biomimetic Tissue Engineering
作者:Hongqiu Wei;Bo Zhang;Ming Lei;Zhe Lu;Jupen Liu;Baolin Guo;You Yu;
关键词:biomineralization,bioactive hydrogels,tough hydrogel,customizable hydrogel,biomimetic tissue engineering
DOI:https://doi.org/10.1021/acsnano.1c11589
发表时间:2022年
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摘要
生物矿化坚韧水凝胶(BTH)在软生物电子学和仿生组织工程领域具有先进的应用。但是,开发用于一步制造可定制 BTH 的快速通用光矿化策略仍然是一项具有挑战性的任务。在这里,我们通过合理设计磷酸盐源和高效的钌光化学,报告了一种简单、低成本的可见光介导的纳米生物矿化(VLMNB)策略。在相同条件下同时构建多网络坚韧水凝胶。因此,在可见光照射下,BTH可以在短短60秒的时间内快速制备。原位形成磷酸钙颗粒可以改善BTH的机械和生物性能,降低与骨骼的摩擦系数。此外,这些 BTH 中的快速生物矿化和凝固过程有利于其可注射和高度灵活的可定制设计,展示了促进可定制皮肤修复和骨骼再生的应用。
Abstract
Biomineralized tough hydrogels (BTHs) have advanced applications in the fields of soft bioelectronics and biomimetic tissue engineering. But the development of rapid and general photomineralization strategies for one-step fabrication of customizable BTHs is still a challenging task. Here we report a straightforward, low-cost visible-light-mediated nano-biomineralization (VLMNB) strategy via a rational design of a phosphate source and efficient ruthenium photochemistry. Multinetwork tough hydrogels are simultaneously constructed under the same condition. Therefore, BTHs are rapidly prepared in a short time as low as ∼60 s under visible light irradiation. The in situ formation of calcium phosphate particles can improve BTHs’ mechanical and biological properties and reduce the friction coefficient with bones. Furthermore, fast biomineralization and solidification processes in these BTHs benefit their injectable and highly flexible customizable design, showing applications of promoting customizable skin repair and bone regeneration.
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