具有定制电催化活性的肽可编程纳米粒子超结构
Peptide-Programmable Nanoparticle Superstructures with Tailored Electrocatalytic Activity
作者:Eun Sung Kang;Yong-Tae Kim;Young-Seon Ko;Nam Hyeong Kim;Geonhee Cho;Yang Hoon Huh;Ji-Hun Kim;Jiyoung Nam;Trung Thanh Thach;David Youn;Young Dok Kim;Wan Soo Yun;William F. DeGrado;Sung Yeol Kim;Paula T
关键词:supramolecular protein self-assembly,artificialy designed peptide,nanoparticle superstructure,electron tomography,Show More
DOI:https://doi.org/10.1021/acsnano.8b01146
发表时间:2018年
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摘要
通过可编程超分子蛋白质组装衍生的生物材料提供了构建精确定义的结构的可行方法。在这里,我们提出了碳纳米管(CNT)上的金铂纳米颗粒(NP)的编程超结构,通过合理调节肽介导的组装,其在纳米颗粒位置方面表现出独特的电催化活性。从头设计的肽沿着碳纳米管轴组装成六螺旋束,形成超螺旋结构。肽的表面半胱氨酸残基产生 AuPt 特异性成核位点,这使得 NP 能够精确定位到螺旋几何形状上,这一点已通过电子断层扫描 3-D 重建得到证实。电催化模型系统,即用于氧还原的 AuPt,产生电化学响应信号,反映了预期组件中纳米颗粒的受控排列。我们的设计方法可以扩展到多种领域,以构建复杂的功能组件。
Abstract
Biomaterials derived via programmable supramolecular protein assembly provide a viable means of constructing precisely defined structures. Here, we present programmed superstructures of AuPt nanoparticles (NPs) on carbon nanotubes (CNTs) that exhibit distinct electrocatalytic activities with respect to the nanoparticle positions via rationally modulated peptide-mediated assembly. De novo designed peptides assemble into six-helix bundles along the CNT axis to form a suprahelical structure. Surface cysteine residues of the peptides create AuPt-specific nucleation site, which allow for precise positioning of NPs onto helical geometries, as confirmed by 3-D reconstruction using electron tomography. The electrocatalytic model system, i.e., AuPt for oxygen reduction, yields electrochemical response signals that reflect the controlled arrangement of NPs in the intended assemblies. Our design approach can be expanded to versatile fields to build sophisticated functional assemblies.
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