Chromatographic methods are commonly used in the pharmaceutical environment for the qualitative and quantitative analysis of raw materials, active pharmaceutical ingredient, drug products, and compounds in biological fluids. Regulatory requirements (1 ) mandate that “the stereoisomeric composition of a drug with a chiral center should be known and the quantitative isomeric composition of the material used in pharmacologic, toxicologic, and clinical studies known. Specifications for the final product should assure identity, strength, quality, and purity from a stereochemical viewpoint.”