膜受体的分类
关键词: 膜 受体来源: 互联网
佚名
随着越来越多的膜表面受体被纯化,其结构及转导信号的方式逐步得以阐明。目前,按照受体的结构及其作用方式可将其分为三大类。这三大类受体在配体种类、受体的一般结构和功能及细胞对之发生反应的方式上有所不同,见表21-2。�
Table 21-2 Classification of Membrane Receptors:Characteristics of Three Groups of Receptors
Characteristics | Ion Channel Receptors | G-Protein-Linked receptors | Recetpors with a Single Transmembrane Domain |
Endogenous ligands | Neurotransmitter | Neurotransmitter | Growth factor hormone |
Hormone | Cytokine | ||
Auloacoid | |||
Chemotactic factor | |||
Exogenous stimulant | |||
Structure | Oligomer with a pore | Probably monomer | Monomer of oligoner |
with (±)catalytic | |||
domain | |||
Number of transmem | Four per subunit | Seven | One per subunit |
bane segments | |||
Function | Ion channel | Activation of G proteins | Tyrosine kinase |
Giuanylate cyclase(?) | |||
Cellular responses | Depolarization or | Depolarization or | Regulation of function |
hyperpolarization | hyperpolarization | and expression of | |
Regulation of function | proteins | ||
and expression of | Proliferation or | ||
proteins | differentiation |
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