An Overview of C. elegans Biology
The establishment of Caenorhabditis elegans as a “model organism” began with the efforts of Sydney Brenner in the early 1960s. Brenner’s focus was to find a suitable animal model in which the tools of genetic analysis could be used to define molecular mechanisms of development and nervous system function. C. elegans provides numerous experimental advantages for such studies. These advantages include a short life cycle, production of large numbers of offspring, easy and inexpensive laboratory culture, forward and reverse genetic tractability, and a relatively simple anatomy. This chapter will provide a brief overview of C. elegans biology.
- Bacteriophage -Based Expression Vectors
- Statistical Comparison of Two or More SAGE Libraries: One Tag at A Time
- Measurement of the Sugar-Binding Specificity of Lectins Using Multiplexed Bead-Based Suspension Arrays
- Nonreplicating DNA Viral Vectors for Suicide Gene Therapy: The Adenoviral Vectors
- Serial Analysis of Gene Expression
- Statistical Analysis of Expressed Sequence Tags
- The Production of Double-Stranded Complementary DNA for Use in Making Libraries
- Analysis of Polymerase Chain Reaction Products by Denaturing High-Performance Liquid Chromatography
- SNaPshot Minisequencing Analysis of Multiple Ancestry-Informative Y-SNPs Using Capillary Electrophoresis
- Assembling Large DNA Segments in Yeast