Biological Applications of Manganese-Enhanced Magnetic Resonance Imaging
The manganese ion (Mn2+ ) has long been used in biomedical research as an indicator of calcium (Ca2+ ) influx in conjunction with fluorescent microscopy because it is well established that Mn2+ enters cells through voltage-gated Ca2+ channels. Mn2+ is also paramagnetic, resulting in a shortening of the spin-lattice relaxation time constant, T1 , which yields positive contrast enhancement in T1 -weighted magnetic resonance imaging (MRI), specific to tissues in which the ion has accumulated. Manganese-enhanced MRI (MEMRI) uses a combination of these properties of Mn2+ to elucidate anatomical information and to identify regions of cellular activity. The focus of this chapter will detail some of the current MEMRI methodologies and biological applications.
- Whole-Genome Allelotyping Using Laser Microdissected Tissue
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- Brain Tumors
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- Hyperpolarized Noble Gases as Contrast Agents
- Frster Resonance Energy Transfer and Trapping in Selected Systems: Analysis by Monte-Carlo Simulation
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