Static Energy Analysis of MHC Class I and Class II Peptide-Binding Affinity
Antigenic peptide is presented to a T-cell receptor (TCR) through the formation of a stable complex with a major histocompatibility complex (MHC) molecule. Various predictive algorithms have been developed to estimate a peptide’s capacity to form a stable complex with a given MHC class II allele, a technique integral to the strategy of vaccine design. These have previously incorporated such computational techniques as quantitative matrices and neural networks. A novel predictive technique is described, which uses molecular modeling of predetermined crystal structures to estimate the stability of an MHC class II–peptide complex. The structures are remodeled, energy minimized, and annealed before the energetic interaction is calculated
- 人肿瘤坏死因子相关弱凋亡诱导因子(TWEAK)酶联免疫分析
- 免疫球蛋白[Ig]超家族的组成
- 与HLAI类抗原关联的疾病
- transkingdom RNA Interference (tkRNAi): A Novel Method to Induce Therapeutic Gene Silencing
- Transcutaneous Immunization
- Isolation and Generation of Clinical-Grade Dendritic Cells Using the CliniMACS System
- In Vitro Development of Human KillerImmunoglobulin Receptor-Positive NK Cells
- Improvement of Proteolytic Stability Through In Silico Engineering
- Immunogold Probes in Light Microscopy
- Determination of CD45 Tyrosine Phosphatase Activity in T Lymphocytes