CD66a/CD66b/CD66c/CD66d/CD66e/CD66f/CD67 分子   CD66a 常用单克隆抗体或代号： BGP- 1 主要表达细胞： G,En [M] 分子质量(kDa)和结构： gp180- 200(胆汁糖蛋白- 1)(IgSF) 功    能： 嗜同性结合,也可识别CD62E   CD66b 常用单克隆抗体或代号： MF25.1;(P100,原CD67,CGM6) 主要表达细胞： G [M] 分子质量(kDa)和结构： gp95- 100,(GPT连接,IgSF) 功    能： CEA家族成员   CD66c 常用单克隆抗体或代号： NCA(无交叉反应抗原) 主要表达细胞： G [M] 分子质量(kDa)和结构： gp90- 95(IgSF) 功    能： CEA家族成员   CD66d 常用单克隆抗体或代号： CGM1 主要表达细胞： G [M] 分子质量(kDa)和结构： Gp30(IgSF) 功    能： CEA家族成员   CD66e 常用单克隆抗体或代号： CLB- gran/10(CEA) 主要表达细胞： G,My,上皮 [M] 分子质量(kDa)和结构： gp180- 200(IgSF) 功    能： 粘附,CEA家族成员   CD66f 常用单克隆抗体或代号： PSG(妊娠特异性抗原) 主要表达细胞： G,M,Mac [M] 分子质量(kDa)和结构： gp54-72 功    能：可能与成功妊娠有关，保护胎儿免受母体免疫系统的损害   CD67 常用单克隆抗体或代号： 改为CD66b   CD66a Aka CEACAM1, biliary glycoprotein, BGP, C-CAM Primordial protein of carcinoembryonic antigen (CEA) family Cell adhesion molecule capable of activating neutrophils; may regulate CD11/CD18 activity Receptor for Neisseria gonorrhea and N. meningitidis Downregulated in colorectal, endometrial and hepatocellular carcinomas; supplementation may cause tumor regression in vitro or in rodents Downregulated in Gleason grade 4/5 prostate carcinoma, Hum Path 2002;33:290 Positive staining (normal): granulocytes, epithelial cells, prostate glands and ducts (dense), bile canaliculi between liver cells Positive staining (disease): low grade prostatic carcinoma Negative staining: prostate carcinoma, Gleason grade 4/5 Micro images (Hum Path subscribers): Prostate: A-normal, B-Gleason grade 3, C-Gleason grade 4, normal liver (figure F)   CD66b Aka CEA gene member 6; formerly CD67 Capable of activating neutrophils; may regulate CD11/CD18 adhesion activity Positive staining (normal): granulocytes Positive staining (disease): chronic myelogenous leukemia   CD66c Aka noncross reactive antigen (NCA) Capable of activating neutrophils; may regulate CD11/CD18 adhesion activity Positive staining (normal): granulocytes   CD66d Capable of activating neutrophils and functions as a receptor for Neisseria gonorrhea and N. meningitidis May play a signaling role and regulate adhesion activity of CD11/CD18 in neutrophils Positive staining (normal): granulocytes   CD66e Aka CEA, carcinoembryonic antigen May play a role in the process of metastasis of cancer cells Serum marker of tumor burden, relapse Removed by hepatic Kupffer cells via a specific receptor. Uses: 85% sensitive, 96% specific for lung adenocarcinomas vs. mesotheliomas; diffuse cylasmic staining with membrane enhancement Positive staining (normal): biliary tract, colon (fetal), epithelial cells (apical surfaces), GI adenocarcinomas (endodermally derived), granulocytes, small intestinal crypts; small intestinal goblet cell mucin (not intracylasmic) Positive staining (tumors): colonic and lung adenocarcinoma, medullary thyroid carcinoma Variable staining: breast carcinoma, endometrial carcinoma, neuroendocrine carcinoma, urothelial carcinoma Negative staining: hepatocellular carcinoma, mesothelioma, ovarian carcinoma, prostate adenocarcinoma, renal cell carcinoma, thyroid carcinoma other than medullary   CD66f Aka pregnancy-specific glycoprotein May be involved in immune regulation, protection of fetus from maternal immune system Low levels in maternal blood predict spontaneous abortion Positive staining (normal): syncytiotrophoblasts, fetal liver, myeloid cell lines Reference: 176390   CD67 Recognizes non-specific cross-reactive antigens present on granulocytes May have role in neutrophil activation ELISA KIT & ANTIBODY OF USCNLIFE